Turning on the Left Side Electrode Changed Depressive State to Manic State in a Parkinson's Disease Patient Who Received Bilateral Subthalamic Nucleus Deep Brain Stimulation: A Case Report.
10.9758/cpn.2018.16.4.494
- Author:
Makoto KINOSHITA
1
;
Masahito NAKATAKI
;
Ryoma MORIGAKI
;
Satsuki SUMITANI
;
Satoshi GOTO
;
Ryuji KAJI
;
Tetsuro OHMORI
Author Information
1. Department of Psychiatry, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima University, Tokushima, Japan. knst5511mkt@sunny.ocn.ne.jp
- Publication Type:Case Report
- Keywords:
Subthalamic nucleus deep brain stimulation;
Parkinson's disease;
Manic episode;
Depressive episode;
Lateral balance
- MeSH:
Aged;
Bipolar Disorder*;
Deep Brain Stimulation*;
Depression;
Electrodes*;
Extremities;
Female;
Humans;
Mood Disorders;
Parkinson Disease*;
Subthalamic Nucleus*;
Tremor
- From:Clinical Psychopharmacology and Neuroscience
2018;16(4):494-496
- CountryRepublic of Korea
- Language:English
-
Abstract:
No previous reports have described a case in which deep brain stimulation elicited an acute mood swing from a depressive to manic state simply by switching one side of the bilateral deep brain stimulation electrode on and off. The patient was a 68-year-old woman with a 10-year history of Parkinson's disease. She underwent bilateral subthalamic deep brain stimulation surgery. After undergoing surgery, the patient exhibited hyperthymia. She was scheduled for admission. On the first day of admission, it was clear that resting tremors in the right limbs had relapsed and her hyperthymia had reverted to depression. It was discovered that the left-side electrode of the deep brain stimulation device was found to be accidentally turned off. As soon as the electrode was turned on, motor impairment improved and her mood switched from depression to mania. The authors speculate that the lateral balance of stimulation plays an important role in mood regulation. The current report provides an intriguing insight into possible mechanisms of mood swing in mood disorders.
