Association of a genetic polymorphism of IL1RN with risk of acute pancreatitis in a Korean ethnic group.
- Author:
Jin Woo PARK
1
;
Ja Sung CHOI
;
Ki Joon HAN
;
Sang Heun LEE
;
Eui Joo KIM
;
Jae Hee CHO
Author Information
- Publication Type:Original Article
- Keywords: Pancreatitis; Polymorphism, single nucleotide; Interleukins; Tumor necrosis factor-alpha
- MeSH: Asian Continental Ancestry Group; DNA; Epidemiologic Studies; Ethnic Groups*; Genotype; Humans; Interleukins; Introns; Pancreatitis*; Polymorphism, Genetic*; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Prospective Studies; Receptors, Interleukin-1; Sequence Analysis, DNA; Tumor Necrosis Factor-alpha
- From:The Korean Journal of Internal Medicine 2018;33(6):1103-1110
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Several epidemiological studies have validated the association of interleukin gene polymorphisms with acute pancreatitis (AP) in different populations. However, there have been few studies in Asian ethnic groups. We aimed to investigate the relationships between inflammatory cytokine polymorphisms and AP as pilot research in a Korean ethnic group. METHODS: Patients who had been diagnosed with AP were prospectively enrolled. DNA was extracted from whole blood, and DNA sequencing was subsequently performed. Single-nucleotide polymorphisms (SNPs) of the interleukin 1β (IL1B), interleukin 1 receptor antagonist (IL1RN), and tumor necrosis factor α (TNFA) genes of patients with AP were compared to those of normal controls. RESULTS: Between January 2011 and January 2013, a total of 65 subjects were enrolled (40 patients with AP vs. 25 healthy controls). One intronic SNP (IL1RN −1129T>C, rs4251961) was significantly associated with the risk of AP (odds ratio, 0.304; 95% confidence interval, 0.095 to 0.967; p = 0.043). However, in our study, AP was not found to be associated with polymorphisms in the promoter regions of inflammatory cytokine genes, including IL1B (−118C>T, c47+242C>T, +3954C/T, and −598T>C) and TNFA (−1211T>C, −1043C>A, −1037C>T, −488G>A, and −418G>A). CONCLUSIONS: IL1RN −1129T>C (rs4251961) genotypes might be associated with a significant increase of AP risk in a Korean ethnic group.
