Age-related Reference Intervals for Total Collagen-I-N-terminal Propeptide in Healthy Korean Population.
10.11005/jbm.2018.25.4.235
- Author:
Jun Il YOO
1
;
Ae Ja PARK
;
Yong Kwan LIM
;
Oh Joo KWEON
;
Jee Hye CHOI
;
Jae Hyuk DO
;
Sunjoo KIM
;
Youngri KIM
;
Yong Chan HA
Author Information
1. Department of Orthopaedic Surgery, Gyeongsang National University Hospital, Jinju, Korea.
- Publication Type:Original Article
- Keywords:
Osteogenesis;
Peptide fragments;
Procollagen;
Procollagen type I N-terminal peptide;
Reference values
- MeSH:
Biomarkers;
Bone Density;
Collagen Type I;
Densitometry;
Female;
Humans;
Male;
Osteogenesis;
Peptide Fragments;
Procollagen;
Reference Values
- From:Journal of Bone Metabolism
2018;25(4):235-241
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Procollagen type I N-terminal propeptide (PINP) is one of the most clinically useful bone formation biomarkers. Therefore, the purpose of this study was to independently evaluate the performance of automated total PINP assay and established age- and gender-specific reference intervals for PINP in healthy Korean population. METHODS: The imprecision, linearity, and detection capability of Elecsys total PINP assay was determined and reference interval was established using 599 serums from Korean population with normal bone mineral densities based on bone densitometry. Age groups were divided into 20s, 30s, 40s, 50s, 60s and over. RESULTS: Elecsys total PINP had excellent performance in imprecision, linearity, and detection capability. When partitioning age groups in Korean male and female populations, there was significant difference in total PINP between different age groups. In male populations, PINP level was decreased with increasing age, then it remained steady after middle-age. In female populations, there was a decreasing tendency similar to that in the male population with a sharp increase in the 50 to 59 age group. CONCLUSIONS: Elecsys total PINP assay showed precise and reliable performance in our study. We established age-related PINP reference intervals for Korean male and female population with normal bone mineral densities.
