A Case of Thyrotoxic Myopathy with Extreme Type 2 Fiber Predominance.
- Author:
Tae Jung KIM
1
;
Han Sang LEE
;
Je Young SHIN
;
Dong Gun KIM
;
Sung Min KIM
;
Jung Joon SUNG
;
Kwang Woo LEE
Author Information
- Publication Type:Case Report
- Keywords: thyrotoxic myopathy; hyperthyroidism; type 2 fiber
- MeSH: Atrophy; Biopsy; Creatine Kinase; Electromyography; Female; Humans; Hyperthyroidism; Leg; Methimazole; Muscles; Muscular Atrophy; Muscular Diseases; Physical Examination; Tachycardia; Thyroid Gland; Thyrotropin; Thyroxine
- From:Experimental Neurobiology 2013;22(3):232-234
- CountryRepublic of Korea
- Language:English
- Abstract: In hyperthyroidism, many patients had neuromuscular symptoms and clinical weakness correlated with free thyroxine (T4) concentrations. The common clinical symptoms of chronic thyrotoxic myopathy were characterized by progressive weakness in proximal muscles and atrophy. A 55-year old woman was visited our hospital with two years of progressive weakness of both legs. Physical examination showed diffuse enlargement of the thyroid gland, muscle atrophy and tachycardia. Motor examination showed proximal weakness in both legs. Serum creatine phosphokinase was normal and electromyography showed a myopathic pattern. Serum thyroxine (T4) was greatly increased and serum thyroid stimulating hormone was very low. Muscle biopsy showed mild atrophic change and type 2 fiber predominance. The patient's symptoms were improved during treatment with methimazole. Herein we report a case of thyrotoxic myopathy with extreme type 2 fiber predominance histologically.
