Effect of Childbirth Age on Bone Mineral Density in Postmenopausal Women.
10.3346/jkms.2018.33.e311
- Author:
Ji Sun WE
1
;
Kyungdo HAN
;
Hyuk Sang KWON
;
Kicheol KIL
Author Information
1. Department of Obstetrics and Gynecology, The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Korea. kilssine@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Maternal Age;
Osteoporosis;
Bone Mineral Density;
Obesity;
Parity
- MeSH:
Body Mass Index;
Bone Density*;
Breast Feeding;
Classification;
Estrogens;
Female;
Humans;
Maternal Age;
Menarche;
Nutrition Surveys;
Obesity;
Osteoporosis;
Osteoporosis, Postmenopausal;
Parity;
Parturition*;
Prevalence;
Reproductive History;
Risk Factors;
Waist Circumference
- From:Journal of Korean Medical Science
2018;33(48):e311-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: In postmenopausal women, there is rapid bone loss due to estrogen depletion. In women, reproductive factors such as age at menarche, breastfeeding, and parity are considered risk factors of osteoporosis. Many reports suggest that obesity is associated with a reduced risk of osteoporosis. This nationwide, population-based study aims to identify the association between maternal age and osteoporosis risk in postmenopausal women of different obesity classifications. METHODS: We assessed data from the Korean National Health and Nutrition Examination Survey 2010–2012. The study included 1,328 postmenopausal women, after excluding women with missing data for reproductive history among 4,546 postmenopausal women in the survey. Multivariate regression was used to identify the association between childbirth age and postmenopausal bone mineral density after adjustments for confounding factors. RESULTS: The prevalence of postmenopausal osteoporosis was 35.24% (n = 468). After dividing the subjects into obese and non-obese groups based on body mass index (BMI) and waist circumference, there were significant differences between non-osteoporosis and osteoporosis groups with regard to age at first childbirth, age at last childbirth, and parity in the BMI-based general obesity group. The prevalence of osteoporosis was highest in women older than 35 years old at last childbirth. The prevalence of osteoporosis was also greater in women with parity ≥ 4 compared to those with lower parity levels. CONCLUSION: Postmenopausal women of older age at last childbirth and higher parity were at increased risk of osteoporosis in the BMI-based non-general obesity group.
