Bioactive Compounds for the Treatment of Renal Disease.
10.3349/ymj.2018.59.9.1015
- Author:
Kang Su CHO
1
;
In Kap KO
;
James J YOO
Author Information
1. Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. jyoo@wakehealth.edu
- Publication Type:Review
- Keywords:
Acute kidney injury;
kidney failure;
chronic;
tissue engineering;
regenerative medicine
- MeSH:
Acute Kidney Injury;
Cell- and Tissue-Based Therapy;
Cytokines;
Developmental Biology;
Dialysis;
Intercellular Signaling Peptides and Proteins;
Kidney;
Kidney Diseases;
Kidney Transplantation;
Kidneys, Artificial;
Recovery of Function;
Regenerative Medicine;
Renal Insufficiency;
Renal Insufficiency, Chronic;
Stem Cells;
Tissue Engineering
- From:Yonsei Medical Journal
2018;59(9):1015-1025
- CountryRepublic of Korea
- Language:English
-
Abstract:
Kidney diseases including acute kidney injury and chronic kidney disease are among the largest health issues worldwide. Dialysis and kidney transplantation can replace a significant portion of renal function, however these treatments still have limitations. To overcome these shortcomings, a variety of innovative efforts have been introduced, including cell-based therapies. During the past decades, advances have been made in the stem cell and developmental biology, and tissue engineering. As part of such efforts, studies on renal cell therapy and artificial kidney developments have been conducted, and multiple therapeutic interventions have shown promise in the pre-clinical and clinical settings. More recently, therapeutic cell-secreting secretomes have emerged as a potential alternative to cell-based approaches. This approach involves the use of renotropic factors, such as growth factors and cytokines, that are produced by cells and these factors have shown effectiveness in facilitating kidney function recovery. This review focuses on the renotropic functions of bioactive compounds that provide protective and regenerative effects for kidney tissue repair, based on the available data in the literature.
