Cord Blood Soluble fms-Like Tyrosine Kinase 1 and Placental Growth Factor in Preterm Infants with Maternal Preeclampsia.
10.12771/emj.2013.36.2.118
- Author:
Jiyoung KIM
1
;
Sujin CHO
;
Young Ju KIM
;
Hye Sook PARK
;
Eun Hee HA
;
Eun Ae PARK
Author Information
1. Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea. pea8639@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Placental growth factor;
Preeclampsia;
Preterm neonates;
Soluble fms-like tyrosine kinase1;
Vascular endothelial growth factor
- MeSH:
Birth Weight;
Female;
Fetal Blood*;
Humans;
Infant;
Infant, Newborn;
Infant, Premature*;
Parental Consent;
Platelet Count;
Pre-Eclampsia*;
Vascular Endothelial Growth Factor A;
Vascular Endothelial Growth Factor Receptor-1*
- From:The Ewha Medical Journal
2013;36(2):118-125
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The purpose of this study was to investigate the relationship of cord blood levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) in preterm infants with maternal preeclampsia. METHODS: Thirty six preterm infants born at Ewha Womans University Mokdong Hospital from January 2006 to August 2006 were studied after prior parental consent at mid-pregnancy. sFlt-1, PlGF, and VEGF levels in the cord blood of preterm neonate, with or without maternal preeclampsia, were measured using enzyme-linked immunosorbent assay. RESULTS: There was no difference in sFlt-1 between infants with and without maternal preeclampsia. Infants with maternal preeclampsia had significantly lower PlGF levels (P=0.035) and higher sFlt-1/PlGF ratio (P=0.080) with borderline significance. Cord blood VEGF levels were not related to maternal preeclampsia. Infants with maternal preeclampsia had lower birth weight (P=0.030), lower neonatal platelet count without statistical significance (P=0.064) and more likely to be small for gestational age (P=0.057). Neonatal platelet count was significantly correlated with cord blood PlGF levels (r=0.674, P=0.032). CONCLUSION: Increased sFlt-1/PlGF ratio and decreased PlGF may not only be related to the pathophysiology of maternal preeclampsia but also affect the neonatal platelet count and birth weight.
