Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans.
10.4062/biomolther.2017.215
- Author:
Eun Byeol LEE
1
;
Jun Hyeong KIM
;
Chang Wan AN
;
Yeong Jee KIM
;
Yun Jeong NOH
;
Su Jin KIM
;
Ju Eun KIM
;
Abinash Chandra SHRESTHA
;
Ha Neul HAM
;
Jae Yoon LEEM
;
Hyung Kwon JO
;
Dae Sung KIM
;
Kwang Hyun MOON
;
Jeong Ho LEE
;
Kyung Ok JEONG
;
Dae Keun KIM
Author Information
1. College of Pharmacy, Woosuk University, Jeonju 55338, Republic of Korea. dkkim@woosuk.ac.kr
- Publication Type:Original Article
- Keywords:
Zingiber officinale Roscoe;
6-Gingerol;
Caenorhabditis elegans;
Longevity;
Stress tolerance
- MeSH:
Caenorhabditis elegans*;
Caenorhabditis*;
Eating;
Ethanol;
Ginger*;
Heat-Shock Proteins;
Humans;
Lipofuscin;
Longevity*;
Natural Resources;
Reactive Oxygen Species;
Reproduction;
Superoxide Dismutase;
Survival Rate
- From:Biomolecules & Therapeutics
2018;26(6):568-575
- CountryRepublic of Korea
- Language:English
-
Abstract:
In order to discover lifespan-extending compounds made from natural resources, activity-guided fractionation of Zingiber officinale Roscoe (Zingiberaceae) ethanol extract was performed using the Caenorhabditis elegans (C. elegans) model system. The compound 6-gingerol was isolated from the most active ethyl acetate soluble fraction, and showed potent longevity-promoting activity. It also elevated the survival rate of worms against stressful environment including thermal, osmotic, and oxidative conditions. Additionally, 6-gingerol elevated the antioxidant enzyme activities of C. elegans, and showed a dose-depend reduction of intracellular reactive oxygen species (ROS) accumulation in worms. Further studies demonstrated that the increased stress tolerance of 6-gingerol-mediated worms could result from the promotion of stress resistance proteins such as heat shock protein (HSP-16.2) and superoxide dismutase (SOD-3). The lipofuscin levels in 6-gingerol treated intestinal worms were decreased in comparison to the control group. No significant 6-gingerol-related changes, including growth, food intake, reproduction, and movement were noted. These results suggest that 6-gingerol exerted longevity-promoting activities independently of these factors and could extend the human lifespan.
