Promotion of excisional wound repair by a menstrual blood-derived stem cell-seeded decellularized human amniotic membrane.
10.1007/s13534-018-0084-1
- Author:
Saeed FARZAMFAR
1
;
Majid SALEHI
;
Arian EHTERAMI
;
Mahdi NASERI-NOSAR
;
Ahmad VAEZ
;
Amir Hassan ZARNANI
;
Hamed SAHRAPEYMA
;
Mohammad Reza SHOKRI
;
Mehdi ALEAHMAD
Author Information
1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. msalehi.te1392@gmail.com
- Publication Type:Original Article
- Keywords:
Amniotic membrane;
Wound healing;
Menstrual blood-derived stem cells
- MeSH:
Amnion*;
Humans*;
Skin;
Stem Cells;
Wound Healing;
Wounds and Injuries*
- From:
Biomedical Engineering Letters
2018;8(4):393-398
- CountryRepublic of Korea
- Language:English
-
Abstract:
This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via decellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM was seeded with MenSCs at the density of 3 × 10⁴ cells/cm² and implanted onto a rat's 1.50 × 1.50 cm² full-thickness excisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSC-seeded DAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicated that the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.
