Minimal Change Disease in Systemic Lupus: Another Renal Manifestation of Lupus?.
10.12771/emj.2013.36.2.139
- Author:
Ki Heon NAM
1
;
Yoon Jin CHA
;
Young Eun KWON
;
Yung Ly KIM
;
Kyoung Sook PARK
;
Seong Yeong AN
;
Beom Jin LIM
;
Hyeon Joo JEONG
;
Hyung Jung OH
;
Tae Hyun YOO
;
Shin Wook KANG
;
Kyu Hun CHOI
;
Seung Hyeok HAN
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. hansh@yuhs.ac
- Publication Type:Case Report
- Keywords:
Lipoid nephrosis;
Systemic lupus erythematosus
- MeSH:
Adrenal Cortex Hormones;
Biopsy;
Cyclophosphamide;
Cyclosporine;
Edema;
Female;
Humans;
Lupus Erythematosus, Systemic*;
Lupus Nephritis;
Mycophenolic Acid;
Nephrosis, Lipoid*;
Nephrotic Syndrome;
Proteinuria;
Young Adult
- From:The Ewha Medical Journal
2013;36(2):139-143
- CountryRepublic of Korea
- Language:English
-
Abstract:
Nephrotic syndrome is most commonly observed in membranous lupus nephritis in patients with systemic lupus erythematosus (SLE). However, other forms of idiopathic nephrotic syndrome rarely occur in these patients. Here, we report a case of SLE complicated by minimal change disease (MCD). A 24-year-old woman with SLE visited our hospital for generalized edema and heavy proteinuria. Laboratory tests did not support immunological exacerbation of lupus, while renal biopsy revealed diffusely effaced foot processes without electron-dense deposits that were consistent with MCD. Administration of high-dose corticosteroids and 6 subsequent cycles of monthly intravenous cyclophosphamide resulted in complete remission. Although nephrotic-range proteinuria recurred 1 month after switching to maintenance therapy with mycophenolate mofetil, complete remission was reestablished after a 6-month treatment with corticosteroids and cyclosporine. Physicians should be cautious in assessment and management of such a rare renal manifestation.
