For Better Fat Graft Outcome in Soft Tissue Augmentation: Systematic Review and Meta-Analysis.
10.14730/aaps.2018.24.3.116
- Author:
Jin Bin KIM
1
;
Han Byeol JIN
;
Ji Hwan SON
;
Jee Hyeok CHUNG
Author Information
1. Department of Plastic and Reconstructive Surgery, MyongJi Hospital, Goyang, Korea. gabriel@mjh.or.kr
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
Adult stem cells;
Analysis of variance;
Autografts
- MeSH:
Adult Stem Cells;
Analysis of Variance;
Autografts;
Breast;
Graft Survival;
Humans;
Methods;
Surgery, Plastic;
Survival Rate;
Transplants*
- From:Archives of Aesthetic Plastic Surgery
2018;24(3):116-127
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Autologous fat grafts are widely used in plastic surgery, but they have the disadvantage of unpredictability due to variable resorption. This meta-analysis examined the literature on the survival rate of autologous fat grafts using objective markers, and investigated the factors that affected the survival rate. METHODS: The reviewers searched the PubMed, EMBASE, and Cochrane Library databases from January 2001 to December 2017. A meta-analysis was performed to estimate fat graft survival and to identify variables that influenced the survival rate. RESULTS: A total of 27 studies (1,066 cases) were included in the meta-analysis. The mean survival rate of grafted fat was 56.5%. The survival rate was significantly higher for cell-assisted lipotransfer (CAL) than for non-CAL (62% vs. 53.4%; P=0.015). The survival rate for procedures performed to correct lipoatrophy was higher than that of procedures performed for other purposes (64.6%; P=0.014), and was significantly higher in patients who underwent breast pre-expansion using the BRAVA device (66.2% vs. 50.35%; P=0.001). There were no significant differences in the survival rate according to the recipient site, harvesting method, or refinement method. CONCLUSIONS: Fat transplantation showed a varying survival rate, with an average of 56%. In patients who underwent CAL or breast pre-expansion with the BRAVA device, the survival rate of transplanted fat was higher than in their counterparts, supporting the use of these techniques in fat transplantation.
