Serial Changes in Mannose-Binding Lectin in Patients with Sepsis.
- Author:
Jin Won HUH
1
;
Kyuyoung SONG
;
Hwa Jung KIM
;
Jung Sun YUM
;
Sang Bum HONG
;
Chae Man LIM
;
Younsuck KOH
Author Information
- Publication Type:Original Article
- Keywords: Mannose-Binding Lectin; Cytokines; Shock, Septic; Prognosis
- MeSH: Chemokine CCL2; Cytokines; Granulocytes; Humans; Interleukin-6; Interleukin-8; Interleukins; Macrophage Colony-Stimulating Factor; Mannose-Binding Lectin*; Prognosis; Sepsis*; Shock, Septic
- From:Tuberculosis and Respiratory Diseases 2018;81(4):305-310
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Mannose-binding lectin (MBL) deficiency leads to increased susceptibility to infection. We investigated whether serial changes in MBL levels are associated with the prognosis of patients diagnosed with septic shock, and correlated with cytokine levels. METHODS: We enrolled 131 patients with septic shock in the study. We analyzed the serum samples for MBL and cytokine levels at baseline and 7 days later. Samples on day 7 were available in 73 patients. RESULTS: We divided the patients with septic shock into four groups according to serum MBL levels ( < 1.3 µg/mL or ≥1.3 µg/mL) on days 1 and 7. Patients with low MBL levels on day 1 and high MBL levels on day 7 showed a favorable prognosis for 28-day survival (odds ratio, 1.96, 95% confidence interval, 1.10–2.87; p=0.087). The high MBL group on day 7 showed a significant decrease in monocyte chemoattractant protein 1, interleukin (IL)-1β, IL-6, IL-8, interferon-γ, and granulocyte macrophage colony-stimulating factor levels compared with the low MBL group on day 7. CONCLUSION: The increase in MBL levels of patients with septic shock may suggest a favorable prognosis and attenuate pro-inflammatory and anti-inflammatory responses.
