Effects of 5HT1A Activation on Depression Profile Following 5-HT Depletion in Rats Lacking Social Attachment Since Weanling.
- Author:
Kuo Jung CHANG
1
;
Yu Jung CHEN
;
Jing Yi CHUNG
;
Chen Cheng LIN
;
Yia Ping LIU
Author Information
- Publication Type:Original Article
- Keywords: 5-HT1A receptors; Depression; Isolation-rearing; Serotonin
- MeSH: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Depression*; Hippocampus; Phenotype; Prefrontal Cortex; Rats*; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Serotonin*; Social Control, Formal; Social Isolation
- From:Psychiatry Investigation 2018;15(10):1000-1006
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: Post weanling isolation-reared (IR) rats are featured with depressive phenotype, yet its mechanism is not clearly defined particularly in terms of the involvement of central 5-HT1A receptors. The present study aims to examine the effects of 5HT1A activation on forced swim test (FST) in IR rats following 5-HT depletion. METHODS: Social control (SOC) and IR rats received an intracerebraoventricular (ICV) injection of 5-HT depletion agent, 5,7-DHT. 14 days after the surgery, rats were assessed their performance in FST with or without the challenge with a 5-HT1A agonist, 8-OH-DPAT. Rats were then sacrificed for analyzing their 5-HT tissue levels and the expressions of their 5-HA1A receptors in prefrontal cortex (PFC), hippocampus (HPX), and amygdala (AMY). RESULTS: 5,7-DHT decreased the tissue concentration of 5-HT in both IR and SOC rats. IR rats were more immobile and less sensitive to the lesion-induced immobility, however this effect was reversed by acute challenge of 8-OH-DPAT. 5,7-DHT lesion increased the expression of PFC 5-HT1A receptors. CONCLUSION: The integrity of central 5-HT system is developmentally crucial for the 5-HT1A-relevant depression profile in rats of social isolation.
