Endoscopic Findings of Children with Familial Mediterranean Fever.
10.5223/pghn.2018.21.4.271
- Author:
Elif SAĞ
1
;
Ferhat DEMIR
;
Ismail SAYGIN
;
Mukaddes KALYONCU
;
Murat ÇAKIR
Author Information
1. Department of Pediatric Gastroenterology, Hepatology and Nutrition, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. muratcak@hotmail.com
- Publication Type:Original Article
- Keywords:
Familial Mediterranean fever;
Gastroscopy;
Colonoscopy;
Inflammatory bowel diseases
- MeSH:
Ambulatory Care Facilities;
Child*;
Colchicine;
Colonoscopy;
Diagnosis;
Endoscopy;
Familial Mediterranean Fever*;
Fever;
Follow-Up Studies;
Gastroenterology;
Gastroscopy;
Humans;
Inflammatory Bowel Diseases;
Odds Ratio;
Pathology;
Serositis;
Synovitis
- From:Pediatric Gastroenterology, Hepatology & Nutrition
2018;21(4):271-277
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Familial Mediterranean fever (FMF) is an auto inflammatory disease characterized by periodic fever, synovitis and serositis. Patients may be admitted to gastroenterology units due to gastrointestinal symptoms. In this study; we aimed to analyze endoscopic findings and diagnostic utility of endoscopic procedure in children with FMF. METHODS: Patient with FMF that was performed endoscopy for the gastrointestinal symptoms were included to the study (39 of 164 patients, 53 procedure). A control group was randomly designed as age and gender matched four endoscopic procedures per one endoscopic procedure of patients with FMF (n=212). RESULTS: No different was found between the patients and control group in esophagogastroscopy findings. However, the diagnosis of gastrointestinal pathology was made by esophagogastroscopy in 46.2% patients. Colonoscopic examination revealed that the frequency of inflammatory bowel disease (IBD) was higher in undiagnosed patients compared to both the control group (50.0% vs. 6.9%, p < 0.05, odds ratio [OR]:13.4 and 95% confidence inteval [95% CI]: 2.1–84.3) and the patients under colchicine treatment (50.0% vs. 8.3%, p < 0.05, OR: 11 and 95% CI: 0.8–147.8). Colonoscopic procedure that was made after the diagnosis was found to provide contribution by 16.7% in determining the etiology of the additional symptoms. CONCLUSION: Patients with FMF may be admitted to pediatric gastroenterology outpatient clinic prior to diagnosis or during the follow-up period. The frequency of IBD is high in undiagnosed patients with FMF. Endoscopic procedures may be helpful in these patients for the diagnosis accompanying mucosal lesions.
