Platycodin D May Improve Acne and Prevent Scarring by Downregulating SREBP-1 Expression Via Inhibition of IGF-1R/PI3K/Akt Pathway and Modulating Inflammation with an Increase in Collagen.
- Author:
Yoorock SUH
1
;
Ji Hoon YANG
;
Ji Young YOON
;
Yu Sung CHOI
Author Information
- Publication Type:Original Article
- Keywords: Acne vulgaris; Acne scar; Collagen; Inflammation; Platycodin D; Sebum
- MeSH: Acne Vulgaris*; Adipokines; Adiponectin; Blotting, Western; Cell Count; Cicatrix*; Collagen*; Fibroblasts; Inflammation*; Keratin-16; Keratinocytes; Lipogenesis; Matrix Metalloproteinases; NF-kappa B; Platycodon; Sebum
- From:Annals of Dermatology 2018;30(5):581-587
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Although many therapeutic agents have been developed, only a few drugs are known to target multiple pathogenic factors in the treatment of acne. OBJECTIVE: The purpose of this study was to identify a new drug candidate, platycodin D, which is a substance extracted from the root of Platycodon grandiflorum. METHODS: Using western blotting and Cell Counting Kit-8 assay, we studied the effects of platycodin D on SEB-1 sebocytes, fibroblasts, and keratinocytes. We investigated its effects in view of lipogenesis, collagen production, anti-inflammatory activity, and dyskeratinization. RESULTS: In SEB-1 sebocytes, platycodin D showed a sebosuppressive effect by downregulating ERK and insulin- like growth factor-1R/PI3K/Akt/sterol-regulatory element binding protein-1 signaling pathways. In addition, adiponectin, one of the adipokines responsible for sebum production, was decreased in platycodin D-treated SEB-1 sebocytes. In fibroblasts, platycodin D increased collagen production and reduced inflammation by inhibiting nuclear factor kappa B and matrix metalloproteinases. Platycodin D also showed anti-inflammatory effects on keratinocytes. It also suppressed keratin 16 expression induced by lipopolysaccharide. Furthermore, platycodin D showed no cytotoxicity on both SEB-1 sebocytes and fibroblasts. CONCLUSION: Our data demonstrate the clinical feasibility of platycodin D for acne treatment and the prevention of acne scarring by sebosuppressive and anti-inflammatory effects, as well as through an increase in collagen levels.
