Lifestyle Risk Prediction Model for Prostate Cancer in a Korean Population.
- Author:
Sung Han KIM
1
;
Sohee KIM
;
Jae Young JOUNG
;
Whi An KWON
;
Ho Kyung SEO
;
Jinsoo CHUNG
;
Byung Ho NAM
;
Kang Hyun LEE
Author Information
- Publication Type:Original Article
- Keywords: Prostate neoplasms; Life style; Decision aids; Forecasting
- MeSH: Alcohol Drinking; Asian Continental Ancestry Group; Body Height; Decision Support Techniques; Early Detection of Cancer; Forecasting; Glucose; Humans; Life Style*; Male; Mass Screening; Meat; Motor Activity; Physical Examination; Population Characteristics; Proportional Hazards Models; Prostate*; Prostate-Specific Antigen; Prostatic Neoplasms*; Risk Factors; Smoke; Smoking
- From:Cancer Research and Treatment 2018;50(4):1194-1202
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The use of prostate-specific antigen as a biomarker for prostate cancer (PC) has been controversial and is, therefore, not used by many countries in their national health screening programs. The biological characteristics of PC in East Asians including Koreans and Japanese are different from those in the Western populations. Potential lifestyle risk factors for PC were evaluated with the aim of developing a risk prediction model. MATERIALS AND METHODS: A total of 1,179,172 Korean men who were cancer free from 1996 to 1997, had taken a physical examination, and completed a lifestyle questionnaire, were enrolled in our study to predict their risk for PC for the next eight years, using the Cox proportional hazards model. The model’s performance was evaluated using the C-statistic and Hosmer–Lemeshow type chi-square statistics. RESULTS: The risk prediction model studied age, height, body mass index, glucose levels, family history of cancer, the frequency of meat consumption, alcohol consumption, smoking status, and physical activity, which were all significant risk factors in a univariate analysis. The model performed very well (C statistic, 0.887; 95% confidence interval, 0.879 to 0.895) and estimated an elevated PC risk in patients who did not consume alcohol or smoke, compared to heavy alcohol consumers (hazard ratio [HR], 0.78) and current smokers (HR, 0.73) (p < 0.001). CONCLUSION: This model can be used for identifying Korean and other East Asian men who are at a high risk for developing PC, as well as for cancer screening and developing preventive health strategies.
