PI3K-Akt-Wnt Pathway Is Implicated in Exercise-Induced Improvement of Short-term Memory in Cerebral Palsy Rats.
- Author:
Jung Wan CHO
1
;
Sun Young JUNG
;
Dae Young KIM
;
Yong Rak CHUNG
;
Hyun Hee CHOI
;
Jung Won JEON
;
Jin Hee HAN
Author Information
- Publication Type:Original Article
- Keywords: Cerebral palsy; Short-term memory; Phosphatidylinositol 3-kinase; Protein kinase B; Glycogen synthase kinase-3β
- MeSH: Animals; Apoptosis; Cell Proliferation; Cerebral Palsy*; Glycogen Synthase; Ligands; Memory, Short-Term*; Neurodevelopmental Disorders; Neurogenesis; Neuronal Plasticity; Parturition; Phosphatidylinositol 3-Kinase; Phosphotransferases; Proto-Oncogene Proteins c-akt; Rats*; Running
- From:International Neurourology Journal 2018;22(Suppl 3):S156-S164
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Maternal lipopolysaccharide (LPS) injection induces neurodevelopmental disorders, such as cerebral palsy. Exercise activates phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) signaling pathway that enhances neurogenesis. Wnt ligands are also implicated in the hippocampal neurogenesis and synaptic plasticity. Glycogen synthase kinase-3β (GSK-3β) is a downstream molecule of Akt, and GSK-3β is known to modulate hippocampal neurogenesis negatively. METHODS: Cerebral palsy was made by maternal LPS-injection. On the 5 weeks after birth, treadmill running was applied to the rat pups of the exercise groups, for 30 minutes, 5 times a week during 6 weeks. RESULTS: Treadmill running alleviated short-term memory impairments of the cerebral palsy rat pups. Hippocampal cell proliferation was increased and hippocampal apoptosis was suppressed by treadmill running in the cerebral palsy rat pups. Hippocampal phosphorylated-PI3K/PI3K ratio, phosphorylated-Akt/Akt ratio, and Wnt expression were enhanced by treadmill running in the cerebral palsy rat pups. In contrast, hippocampal phosphorylated-GSK-3β/GSK-3β ratio and β-catenin expression were suppressed by treadmill running in the cerebral palsy rat pups. CONCLUSIONS: The results of this study showed that short-term memory improvement due to treadmill running in cerebral palsy occurs via activation of the PI3K-Akt-Wnt pathway.
