Decreased Expression of Sphingosine-1-Phosphate Receptor 1 in the Blood Leukocyte of Rheumatoid Arthritis Patients.
- Author:
Hyun Suk CHOI
1
;
Kyong Hoon KIM
;
Seohoon JIN
;
Jinhyun KIM
;
Inseol YOO
;
Seung Pil PACK
;
Un Hwan HA
;
Tae Won PARK
;
Soo An CHOI
;
Soon Hong YUK
;
Seong Wook KANG
;
Yong Woo JUNG
Author Information
- Publication Type:Brief Communication
- Keywords: Sphingosine-1-phosphate; Rheumatoid arthritis; S1P receptor; Leukocytes
- MeSH: Arthritis, Rheumatoid*; Autoimmunity; Humans; Immune System Diseases; Leukocytes*; Receptors, Lysosphingolipid*; RNA, Messenger; Synovial Membrane
- From:Immune Network 2018;18(5):e39-
- CountryRepublic of Korea
- Language:English
- Abstract: Sphingosine-1-phosphate (S1P) plays an important role in trafficking leukocytes and developing immune disorders including autoimmunity. In the synovium of rheumatoid arthritis (RA) patients, increased expression of S1P was reported, and the interaction between S1P and S1P receptor 1 (S1P1) has been suggested to regulate the expression of inflammatory genes and the proliferation of synovial cells. In this study, we investigated the level of S1P1 mRNA expression in the blood leukocytes of RA patients. In contrast to the previous reports, the expression level of this gene was not correlated to their clinical scores, disease durations and ages. However, S1P1 was transcribed at a significantly lower level in the circulating leukocytes of RA patients when compared to age-, and sex-matched healthy controls. Since these data may suggest the participation of S1P1, further studies are needed to determine the role of this receptor in the pathogenesis of RA.
