Chronic Hepatitis B Infection Is Significantly Associated with Chronic Kidney Disease: a Population-based, Matched Case-control Study.
10.3346/jkms.2018.33.e264
- Author:
Sung Eun KIM
1
;
Eun Sun JANG
;
Moran KI
;
Geum Youn GWAK
;
Kyung Ah KIM
;
Gi Ae KIM
;
Do Young KIM
;
Dong Joon KIM
;
Man Woo KIM
;
Yun Soo KIM
;
Young Seok KIM
;
In Hee KIM
;
Chang Wook KIM
;
Ho Dong KIM
;
Hyung Joon KIM
;
Neung Hwa PARK
;
Soon Koo BAIK
;
Jeong Ill SUH
;
Byung Cheol SONG
;
Il Han SONG
;
Jong Eun YEON
;
Byung Seok LEE
;
Youn Jae LEE
;
Young Kul JUNG
;
Woo Jin CHUNG
;
Sung Bum CHO
;
Eun Young CHO
;
Hyun Chin CHO
;
Gab Jin CHEON
;
Hee Bok CHAE
;
DaeHee CHOI
;
Sung Kyu CHOI
;
Hwa Young CHOI
;
Won Young TAK
;
Jeong HEO
;
Sook Hyang JEONG
Author Information
1. Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Hepatitis B Virus;
Chronic Renal Insufficiency;
Glomerular Filtration Rate;
Proteinuria
- MeSH:
Anemia;
Antigens, Surface;
Bilirubin;
Case-Control Studies*;
Female;
Glomerular Filtration Rate;
Hepatitis B Surface Antigens;
Hepatitis B virus;
Hepatitis B, Chronic*;
Hepatitis, Chronic*;
Humans;
Male;
Multivariate Analysis;
Prevalence;
Proteinuria;
Renal Insufficiency, Chronic*
- From:Journal of Korean Medical Science
2018;33(42):e264-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study investigated the association between chronic HBV infection and CKD in a nationwide multicenter study. METHODS: A total of 265,086 subjects who underwent health-check examinations in 33 hospitals from January 2015 to December 2015 were enrolled. HBV surface antigen (HBsAg) positive cases (n = 10,048), and age- and gender-matched HBsAg negative controls (n = 40,192) were identified. CKD was defined as a glomerular filtration rate (GFR) < 60 mL/min/1.73 m² or proteinuria as at least grade 2+ of urine protein. RESULTS: HBsAg positive cases showed a significantly higher prevalence of GFR < 60 mL/min/1.73 m² (3.3%), and proteinuria (18.9%) than that of the controls (2.6%, P < 0.001, and 14.1%, P < 0.001, respectively). In the multivariate analysis, HBsAg positivity was an independent factor associated with GFR < 60 mL/min/1.73 m² along with age, blood levels of albumin, bilirubin, anemia, and hemoglobin A1c (HbA1c). Likewise, HBsAg positivity was an independent factor for proteinuria along with age, male, blood levels of bilirubin, protein, albumin, and HbA1c. A subgroup analysis showed that HBsAg positive men but not women had a significantly increased risk for GFR < 60 mL/min/1.73 m². CONCLUSION: Chronic HBV infection was significantly associated with a GFR < 60 mL/min/1.73 m² and proteinuria (≥ 2+). Therefore, clinical concern about CKD in chronic HBV infected patients, especially in male, is warranted.
