Injectable Biomaterials in Plastic and Reconstructive Surgery: A Review of the Current Status.
10.1007/s13770-018-0158-2
- Author:
Ki Hyun CHO
1
;
Saji UTHAMAN
;
In Kyu PARK
;
Chong Su CHO
Author Information
1. Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA.
- Publication Type:Review
- Keywords:
Injectable biomaterials;
Adipose-derived stem cells;
Adipose tissue;
Tissue regeneration;
Plastic and reconstructive surgery
- MeSH:
Adipose Tissue;
Biocompatible Materials*;
Intercellular Signaling Peptides and Proteins;
Methods;
Plastics*;
Regeneration;
Stem Cells
- From:
Tissue Engineering and Regenerative Medicine
2018;15(5):559-574
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Injectable biomaterials have attracted increasing attention for volume restoration and tissue regeneration. The main aim of this review is to discuss the current status of the injectable biomaterials for correction of tissue defects in plastic and reconstructive surgery. METHODS: Requirements of injectable biomaterials, mechanism of in situ gelation, characteristics, and the combinational usage of adipose-derived stem cells (ADSCs) and growth factors were reviewed. RESULTS: The ideal injectable biomaterials should be biocompatible, non-toxic, easy to use, and cost-effective. Additionally, it should possess adequate mechanical properties and stability. In situ gelation method includes physical, chemical, enzymatic and photo-initiated methods. Natural and synthetic biomaterials carry their pros and cons due to their inherent properties. The combined use of ADSCs and growth factors provides enhanced potential for adipose tissue regeneration. CONCLUSION: The usage of injectable biomaterials has been increasing for the tissue restoration and regeneration. The future of incorporating ADSCs and growth factors into the injectable biomaterials is promising.
