Biopolymeric In Situ Hydrogels for Tissue Engineering and Bioimaging Applications.
10.1007/s13770-018-0159-1
- Author:
Adonijah Graham SONTYANA
1
;
Ansuja Pulickal MATHEW
;
Ki Hyun CHO
;
Saji UTHAMAN
;
In Kyu PARK
Author Information
1. Department of Biomedical Sciences, Chonnam National University, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju 61469, Republic of Korea. pik96@jnu.ac.kr
- Publication Type:Review
- Keywords:
Bioimaging;
Biopolymeric injectable hydrogels;
Gelation
- MeSH:
Biopolymers*;
Hydrogel*;
Hydrogels*;
Regenerative Medicine;
Tissue Engineering*
- From:
Tissue Engineering and Regenerative Medicine
2018;15(5):575-590
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Biopolymeric in situ hydrogels play a crucial role in the regenerative repair and replacement of infected or injured tissue. They possess excellent biodegradability and biocompatibility in the biological system, however only a few biopolymeric in situ hydrogels have been approved clinically. Researchers have been investigating new advancements and designs to restore tissue functions and structure, and these studies involve a composite of biometrics, cells and a combination of factors that can repair or regenerate damaged tissue. METHODS: Injectable hydrogels, cross-linking mechanisms, bioactive materials for injectable hydrogels, clinically applied injectable biopolymeric hydrogels and the bioimaging applications of hydrogels were reviewed. RESULTS: This article reviews the different types of biopolymeric injectable hydrogels, their gelation mechanisms, tissue engineering, clinical applications and their various in situ imaging techniques. CONCLUSION: The applications of bioactive injectable hydrogels and their bioimaging are a promising area in tissue engineering and regenerative medicine. There is a high demand for injectable hydrogels for in situ imaging.
