Trends in Gallbladder Cancer Incidence and Survival in Korea.
- Author:
Youngjun WI
1
;
Hyeongtaek WOO
;
Young Joo WON
;
Jin Young JANG
;
Aesun SHIN
Author Information
- Publication Type:Original Article
- Keywords: Gallbladder neoplasms; Epidemiology; Incidence; Survival; Geographic variation
- MeSH: Adenocarcinoma; Epidemiology; Female; Gallbladder Neoplasms*; Gallbladder*; Gyeonggi-do; Gyeongsangnam-do; Humans; Incidence*; Korea*; Male; Sex Characteristics; Ulsan
- From:Cancer Research and Treatment 2018;50(4):1444-1451
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The current study was undertaken to examine the trend in gallbladder cancer (GBC) incidenceand survival in Korea. MATERIALS AND METHODS: GBC incidence data by histologic typewere obtained from the Korea Central Cancer Registry.Age-standardized incidence rates were calculated using the mid-year Korean population of2000 as a standard population, and a joinpoint regression model was used to calculate theannual percent change (APC) in incidence rates. Incidence by Surveillance, Epidemiology and End Results (SEER) summary stage and by geographical areas and female-to-male incidencerate ratios was also described. RESULTS: The number of new GBC cases increased between 1999 and 2013. Nevertheless, the agestandardizedincidence rate decreased by 0.5% per year in men (p < 0.01), whereas theincidence rate in women did not change significantly over the same period (APC, –0.2;p=0.59). The most common histologic type was adenocarcinoma in both sexes. Based onthe SEER stage, the distant stage was the most frequent stage (41%), followed by theregional stage (37%). Ulsan (4.31/100,000 for men and 4.09/100,000 forwomen in 2009-2013) and Gyeongsangnam-do (4.15/100,000 for men and 3.54/100,000 for women)showed the highest GBC incidence, whereas the lowest incidence was observed in Seouland Gyeonggi-do. There were no significant sex differences in the incidence of GBC (femaleto-maleincidence rate ratio, 0.96). CONCLUSION: The overall incidence of GBC in Korea did not change significantly over the 15-year period.Incidence for men and women was similar. However, geographical variation was found.
