The Efficacy and Safety of Direct-acting Antiviral Treatment for Chronic Hepatitis C Patients: A Single Center Study.
10.4166/kjg.2018.72.4.197
- Author:
Seong Jun PARK
1
;
Ah Ran KIM
;
Won Hyeok CHOE
;
Jeong Han KIM
;
Byung Chul YOO
;
So Young KWON
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea. sykwonmd@hotmail.com
- Publication Type:Original Article
- Keywords:
Hepatitis C, chronic;
Antiviral agents;
Sustained virologic response
- MeSH:
Anemia;
Antiviral Agents;
Bradycardia;
Dyspepsia;
Elasticity Imaging Techniques;
Fibrosis;
Genotype;
Hepatitis C, Chronic*;
Hepatitis, Chronic*;
Humans;
Liver;
Liver Cirrhosis;
Male;
Retrospective Studies;
Sleep Initiation and Maintenance Disorders
- From:The Korean Journal of Gastroenterology
2018;72(4):197-204
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Direct-acting antiviral (DAA) therapy has been shown to achieve a high rate of sustained virologic response (SVR) and favorable outcomes in chronic hepatitis C (CHC) patients. We investigated the virologic response and its clinical impact in CHC patients. METHODS: CHC patients with compensated liver function treated with DAAs between 2016 and 2017 were included for retrospective analysis. We analyzed baseline characteristics and virologic and biochemical responses at on-treatment 4 weeks, end of treatment, and post-treatment 12 weeks. Fibrosis was measured as liver stiffness measurement by transient elastography (FibroScan). Adverse events were monitored during the treatment period. RESULTS: A total of 135 patients (61.5% with genotype [GT] 1b and 38.5% with GT 2a) were enrolled 47.4% were male, 79.3% were treatment naive, and 30.4% had cirrhosis. SVR 12 was observed in 97.6% (81/83) in the GT 1b and 98.1% (51/52) in the GT 2a; treatment with daclatasvir+asunaprevir was the most commonly used in GT 1b (55/83), and sofosbuvir+ribavirin was the most commonly used in GT 2a (49/52). The median change of liver stiffness measurement at two time points using the signed rank test was -3.2 kPa in patients who underwent transient elastography before treatment and at SVR 12 (n=25). The most common adverse events were anemia, dyspepsia, and insomnia. One GT 2a patient treated with sofosbuvir+ribavirin stopped the treatment at 8 weeks due to symptomatic bradyarrhythmia; however, he recovered spontaneously and achieved SVR 12. CONCLUSIONS: DAA treatment of chronic hepatitis C genotype 1b and 2a resulted in a high rate of sustained virologic response and improvement of liver fibrosis score.
