Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis.
- Author:
Seo Jun KANG
1
;
Jin Soo KIM
;
Sang Myun PARK
Author Information
- Publication Type:Original Article
- Keywords: alpha-synuclein; UCH-L1; Parkinson's disease; prion disease
- MeSH: alpha-Synuclein; Alzheimer Disease; Caveolin 1; Endocytosis*; Neurodegenerative Diseases; Neurons; Parkinson Disease; Prion Diseases; Ubiquitin Thiolesterase*; Ubiquitin*
- From:Experimental Neurobiology 2018;27(5):377-386
- CountryRepublic of Korea
- Language:English
- Abstract: Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed in neurons, and gathering evidence indicates that UCH-L1 may play pathogenic roles in many neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease (PD). Additionally, lipid rafts have attracted interest in neurodegeneration as playing a common role in many neurodegenerative diseases. In the present study, we demonstrated that UCH-L1 associates with lipid rafts as with other PD-associated gene products. In addition, UCH-L1 regulates lipid raft-dependent endocytosis and it is not dependent on the expression and degradation of caveolin-1 or flotillin-1. Finally, UCH-L1 regulates cell-to-cell transmission of α-synuclein. This study provides evidence that many PD-associated gene products share common signaling pathways to explain the pathogenesis of PD.
