Various Clinical Presentation of Post-Transplant Lymphoproliferative Disorder in Head and Neck: A Case Series of 3 Patients.
10.3342/kjorl-hns.2017.00073
- Author:
Hee Jung KIM
1
;
Sang Joon CHOI
;
Young Hyeh KO
;
Nayeon CHOI
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. chlskduschoi@naver.com
- Publication Type:Case Report
- Keywords:
Head and neck;
Immunosuppressive agent;
Post-transplant lymphoproliferative disorder
- MeSH:
Adenoids;
Bone Marrow Transplantation;
Brain;
Diagnosis;
Head*;
Humans;
Immunosuppressive Agents;
Lymph Nodes;
Lymphoproliferative Disorders*;
Neck*;
Palatine Tonsil;
Prognosis
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2018;61(10):536-540
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The outcome of solid organ and bone marrow transplantation has been dramatically improved with the development of immunosuppressive agent. However, the use of immunosuppressive agents could increase the risk of malignancies such as post-transplant lymphoproliferative disorder (PTLD). PTLD is regarded as the lymphoid malignancy of patients using immunosuppressive agents, and it could present diverse and non-specific symptoms. It involves various organs including the tonsil, adenoid, lymph node, and the brain. Because of its poor prognosis, an early suspicion of pathologic diagnosis is crucial for the treatment of PTLD. In this report, we demonstrate the case of three pediatric patients who had been treated for PTLD of various clinical presentations by early suspicion and pathologic diagnosis.
