Stem cell transplantation and functional recovery after spinal cord injury: a systematic review and meta-analysis.
10.5115/acb.2018.51.3.180
- Author:
Hojjat Allah ABBASZADEH
1
;
Somayeh NIKNAZAR
;
Shahram DARABI
;
Navid AHMADY ROOZBAHANY
;
Ali NOORI-ZADEH
;
Seyed Kamran GHOREISHI
;
Maryam Sadat KHORAMGAH
;
Yousef SADEGHI
Author Information
1. Hearing Disorders Research Center, Loghman Hakim Medical Center and Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
Stem cell therapy;
Spinal cord injuries;
Meta-analysis;
Contusions
- MeSH:
Cell- and Tissue-Based Therapy;
Contusions;
Models, Animal;
Spinal Cord Injuries*;
Spinal Cord*;
Stem Cell Transplantation*;
Stem Cells*
- From:Anatomy & Cell Biology
2018;51(3):180-188
- CountryRepublic of Korea
- Language:English
-
Abstract:
Spinal cord injury is a significant cause of motor dysfunctions. There is no definite cure for it, and most of the therapeutic modalities are only symptomatic treatment. In this systematic review and meta-analysis, the effectiveness of stem cell therapy in the treatment of the spinal cord injuries in animal models was studied and evaluated. A systematic search through medical databases by using appropriate keywords was conducted. The relevant reports were reviewed in order to find out cases in which inclusion and exclusion criteria had been fulfilled. Finally, 89 articles have been considered, from which 28 had sufficient data for performing statistical analyses. The findings showed a significant improvement in motor functions after cell therapy. The outcome was strongly related to the number of transplanted cells, site of injury, chronicity of the injury, type of the damage, and the induction of immune-suppression. According to our data, improvements in functional recovery after stem cell therapy in the treatment of spinal cord injury in animal models was noticeable, but its outcome is strongly related to the site of injury, number of transplanted cells, and type of transplanted cells.
