Dihydroxyadenine crystal-induced nephropathy presenting with rapidly progressive renal failure.
10.23876/j.krcp.2018.37.3.287
- Author:
Ritu VERMA
1
;
Manickam NIRAIMATHI
;
Pallavi PRASAD
;
Vinita AGRAWAL
Author Information
1. Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. dr_rituverma@rediffmail.com
- Publication Type:Case Report
- Keywords:
Adenine phosphoribosyltransferase;
Crystal nephropathy;
Dihydroxyadenine crystals
- MeSH:
Adenine Phosphoribosyltransferase;
Biopsy;
Early Diagnosis;
Female;
Humans;
Renal Insufficiency*;
Urolithiasis
- From:Kidney Research and Clinical Practice
2018;37(3):287-291
- CountryRepublic of Korea
- Language:English
-
Abstract:
Adenine phosphoribosyltransferase enzyme deficiency is a rare, autosomal recessive disorder. It is a disease limited to the renal system and usually presents with urolithiasis. Herein, we report a young female with dihydroxyadenine (DHA) crystal-induced nephropathy presenting with rapidly progressive renal failure. DHA crystals can be easily diagnosed by their pathognomic color and shape in urine and biopsy specimens. A high index of clinical suspicion helps in the early diagnosis of this potentially treatable renal disease.
