Report on the External Quality Assessment Scheme for Metabolite Testing in Korea (2016–2017).
10.15263/jlmqa.2018.40.3.136
- Author:
Soo Youn LEE
1
Author Information
1. Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. suddenbz@skku.edu
- Publication Type:Review
- Keywords:
External quality assessment;
Newborn screening;
Tandem mass spectrometry;
Amino acid;
Organic acid;
Metabolite
- MeSH:
Adrenal Hyperplasia, Congenital;
Amino Acids;
Catecholamines;
Congenital Hypothyroidism;
Education;
Galactosemias;
Homocystinuria;
Humans;
Infant, Newborn;
Korea*;
Maple Syrup Urine Disease;
Mass Screening;
Methylmalonic Acid;
Phenylketonurias;
Tandem Mass Spectrometry;
Vanilmandelic Acid
- From:Journal of Laboratory Medicine and Quality Assurance
2018;40(3):136-148
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
External quality assessment (EQA) trials of conventional newborn screening tests for phenylketonuria, galactosemia, congenital adrenal hyperplasia, maple syrup urine disease, homocystinuria, and congenital hypothyroidism, as well as extended newborn screening tests using tandem mass spectrometry, were performed twice in 2016 and 2017. A total of 44 specimens in the form of dried blood spots were distributed in each trial to 16 laboratories. The response rate of these laboratories was 100%. The mean, standard deviation, coefficient of variation, median, and cut-offs were evaluated for each analyte in the newborn screening tests. EQA trials for the analyses of methylmalonic acid, vanillylmandelic acid, catecholamines, metanephrines, organic acids, and amino acids were also performed. A well-designed EQA program and continuous education would improve the performance of metabolite testing.
