Successful Salvage Unrelated Umbilical Cord Blood Transplantation with Two Units After Engraftment Failure with Single Unit in Severe Aplastic Anemia.
10.3346/jkms.2009.24.4.744
- Author:
Ji Won LEE
1
;
Hyoung Jin KANG
;
Eun Kyung KIM
;
Hee Young SHIN
;
Hyo Seop AHN
Author Information
1. Division of Hematology/Oncology, Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. hsahn@snu.ac.kr
- Publication Type:Case Report ; Research Support, Non-U.S. Gov't
- Keywords:
Anemia, Aplastic;
Cord Blood Stem Cell Transplantation;
Two-unit
- MeSH:
Anemia, Aplastic/diagnosis/*therapy;
Child, Preschool;
*Cord Blood Stem Cell Transplantation;
Female;
Graft vs Host Disease/immunology;
HLA Antigens/immunology;
Histocompatibility;
Humans;
In Situ Hybridization, Fluorescence
- From:Journal of Korean Medical Science
2009;24(4):744-746
- CountryRepublic of Korea
- Language:English
-
Abstract:
Severe aplastic anemia (SAA) patients without an HLA-matched sibling donor need alternative treatment options. Umbilical cord blood transplantation (UCBT) has become an alternative means for treating various diseases, but it has not been proved to be a satisfactory method to treat SAA. Here, we report the case of a girl who underwent successful two-unit UCBT after engraftment failure with a single unit. Twounit UCBT is proposed to have better engraftment potential and to offer a better chance of survival, according to some reports. Increased cell dose and graft-versus-graft reaction could contribute to these advantages. With this promising result, two-unit UCBT could be an alternative treatment option for patients with SAA without an HLA-matched donor.
