Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy.
10.3346/jkms.2009.24.4.760
- Author:
Jinyung JU
1
;
Yong Soo KWON
;
Kae Jung JO
;
Dong Ryeol CHAE
;
Jung Hwan LIM
;
Hee Jung BAN
;
Su Young CHI
;
In Jae OH
;
Ku Sik KIM
;
Yu Il KIM
;
Young Chul KIM
;
Sung Chul LIM
Author Information
1. Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea. lscmd@jnu.ac.kr
- Publication Type:Case Report
- Keywords:
Histiocytosis, Sinus;
Massive Lymphadenopathy;
Rosai-Dorfman Disease
- MeSH:
Adult;
Antigens, CD/metabolism;
Antigens, Differentiation, Myelomonocytic/metabolism;
Histiocytes/pathology;
Histiocytosis, Sinus/*diagnosis/metabolism/pathology;
Humans;
Lymph Nodes/pathology;
Male;
Neck;
Pleural Effusion/*radiography;
S100 Proteins/metabolism;
Tomography, X-Ray Computed
- From:Journal of Korean Medical Science
2009;24(4):760-762
- CountryRepublic of Korea
- Language:English
-
Abstract:
Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder characterized by a nonneoplastic proliferation of distinctive histiocyte cells within lymph node sinuses and lymphatics in extranodal sites. SHML occurs worldwide and is primarily a disease of childhood and early adulthood. A 26-yr-old man presented with painless palpable lymph node in cervical area. Radiographic studies revealed pleural effusion with lymphadenopathy and calcification in mediastinum. The cervical lymph node biopsy showed dilated sinuses filled with histiocytes with clear cytoplasm. The cells stained positive with CD68 and S-100. These cytologic and immunohistochemical findings were considered consistent with the diagnosis of SHML.
