Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients.
10.3803/EnM.2018.33.3.364
- Author:
Ji Sun NAM
1
;
Jung Woo HAN
;
Sang Bae LEE
;
Ji Hong YOU
;
Min Jin KIM
;
Shinae KANG
;
Jong Suk PARK
;
Chul Woo AHN
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. acw@yuhs.ac
- Publication Type:Original Article
- Keywords:
Calpain 10;
Adiponectin;
Diabetes mellitus, type 2
- MeSH:
Adiponectin*;
Diabetes Mellitus, Type 2;
Genetic Variation;
Genotype;
Glucose;
Humans;
Insulin;
Insulin Resistance;
Introns;
Metabolism;
Polymorphism, Single Nucleotide
- From:Endocrinology and Metabolism
2018;33(3):364-371
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients. METHODS: Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes. RESULTS: Among calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion. CONCLUSION: Variations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism.
