Effects of Maternal Iodine Status during Pregnancy and Lactation on Maternal Thyroid Function and Offspring Growth and Development: A Prospective Study Protocol for the Ideal Breast Milk Cohort.
10.3803/EnM.2018.33.3.395
- Author:
Young Ah LEE
1
;
Sun Wook CHO
;
Ho Kyung SUNG
;
Kyungsik KIM
;
Young Shin SONG
;
Sin Je MOON
;
Jung Won OH
;
Dal Lae JU
;
Sooyeon CHOI
;
Sang Hoon SONG
;
Gi Jeong CHEON
;
Young Joo PARK
;
Choong Ho SHIN
;
Sue K PARK
;
Jong Kwan JUN
;
June Key CHUNG
Author Information
1. Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Iodine intake;
Pregnancy;
Milk, human;
Thyroid;
Infant;
Development
- MeSH:
Breast*;
Child;
Cohort Studies*;
Cordocentesis;
Diet Records;
Female;
Growth and Development*;
Humans;
Infant;
Iodine*;
Korea;
Lactation*;
Milk, Human*;
Parturition;
Postpartum Period;
Pregnancy Trimester, Third;
Pregnancy*;
Pregnant Women;
Prospective Studies*;
Seaweed;
Seoul;
Thyroid Diseases;
Thyroid Function Tests;
Thyroid Gland*;
Twins;
Ultrasonography
- From:Endocrinology and Metabolism
2018;33(3):395-402
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Iodine is an intrinsic element of thyroid hormone, which is essential for childhood growth and development. The Ideal Breast Milk (IBM) cohort study aims to evaluate the effects of maternal iodine status during pregnancy and lactation on maternal thyroid function, offspring growth and development, and offspring thyroid function. METHODS: The IBM cohort study recruited pregnant women from Seoul National University Hospital between June 2016 and August 2017, followed by enrollment of their offspring after delivery. For the maternal participants, iodine status is evaluated by urinary iodine concentration (UIC) and dietary records in the third trimester and at 3 to 4 weeks and 12 to 15 months postpartum. For the child participants, cord blood sampling and UIC measurements are performed at birth. At 3 to 4 weeks of age, UIC and breastmilk iodine concentrations are measured. At 12 to 15 months of age, growth and development are assessed and measurements of UIC, a thyroid function test, and ultrasonography are performed. RESULTS: A total of 198 pregnant women in their third trimester were recruited. Their mean age was 35.1±3.5 years, and 78 (39.4%) of them were pregnant with twins. Thirty-three (16.7%) of them had a previous history of thyroid disease. CONCLUSION: Korea is an iodine-replete area. In particular, lactating women in Korea are commonly exposed to excess iodine due to the traditional practice of consuming brown seaweed soup postpartum. The study of the IBM cohort is expected to contribute to developing guidelines for optimal iodine nutrition in pregnant or lactating women.
