¹⁸F-THK5351 PET Imaging in Nonfluent-Agrammatic Variant Primary Progressive Aphasia.
10.12779/dnd.2018.17.3.110
- Author:
Cindy W YOON
1
;
Hye Jin JEONG
;
Seongho SEO
;
Sang Yoon LEE
;
Mee Kyung SUH
;
Jae Hyeok HEO
;
Yeong Bae LEE
;
Kee Hyung PARK
;
Nobuyuki OKAMURA
;
Kyoung Min LEE
;
Young NOH
Author Information
1. Department of Neurology, Inha University School of Medicine, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
Primary Progressive Nonfluent Aphasia;
tau Protein;
Neurofibrillary Tangles;
Positron Emission Tomography
- MeSH:
Alzheimer Disease;
Aphasia, Primary Progressive*;
Basal Ganglia;
Broca Area;
Diagnosis;
Frontal Lobe;
Humans;
Magnetic Resonance Imaging;
Neurofibrillary Tangles;
Neuropsychological Tests;
Positron-Emission Tomography;
Primary Progressive Nonfluent Aphasia;
tau Proteins
- From:Dementia and Neurocognitive Disorders
2018;17(3):110-119
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND PURPOSE: To analyze 18F-THK5351 positron emission tomography (PET) scans of patients with clinically diagnosed nonfluent/agrammatic variant primary progressive aphasia (navPPA). METHODS: Thirty-one participants, including those with Alzheimer's disease (AD, n=13), navPPA (n=3), and those with normal control (NC, n=15) who completed 3 Tesla magnetic resonance imaging, 18F-THK5351 PET scans, and detailed neuropsychological tests, were included. Voxel-based and region of interest (ROI)-based analyses were performed to evaluate retention of 18F-THK5351 in navPPA patients. RESULTS: In ROI-based analysis, patients with navPPA had higher levels of THK retention in the Broca's area, bilateral inferior frontal lobes, bilateral precentral gyri, and bilateral basal ganglia. Patients with navPPA showed higher levels of THK retention in bilateral frontal lobes (mainly left side) compared than NC in voxel-wise analysis. CONCLUSIONS: In our study, THK retention in navPPA patients was mainly distributed at the frontal region which was well correlated with functional-radiological distribution of navPPA. Our results suggest that tau PET imaging could be a supportive tool for diagnosis of navPPA in combination with a clinical history.
