C-Reactive Protein to Serum Albumin Ratio Is an Independent Predictor of All-Cause Mortality in Patients with ANCA-Associated Vasculitis.
10.3349/ymj.2018.59.7.865
- Author:
Jae Seung MOON
1
;
Sung Soo AHN
;
Yong Beom PARK
;
Sang Kyou LEE
;
Sang Won LEE
Author Information
1. Department of Biotechnology, Yonsei University College of Life Science and Biotechnology, Seoul, Korea. sjrlee@yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Antineutrophil cytoplasmic antibody;
vasculitis;
c-reactive protein;
albumin;
mortality
- MeSH:
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis*;
Antibodies, Antineutrophil Cytoplasmic;
C-Reactive Protein*;
Diabetes Mellitus;
Diagnosis;
Eosinophils;
Follow-Up Studies;
Granulomatosis with Polyangiitis;
Humans;
Hypertension;
Male;
Medical Records;
Microscopic Polyangiitis;
Mortality*;
Proportional Hazards Models;
Renal Insufficiency, Chronic;
Retrospective Studies;
Risk Factors;
Serum Albumin*;
Vasculitis
- From:Yonsei Medical Journal
2018;59(7):865-871
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We investigated whether C-reactive protein (CRP) to serum albumin ratio (CAR) could be an independent predictor of all-cause mortality in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 170 patients with AAV. We collected clinical and laboratory data. We also examined AAV-related and traditional risk factors of all-cause mortality. To assess the hazard ratios of variables, we performed univariable and multivariable Cox hazard model analyses. RESULTS: The mean age was 55.0 years and 53 patients (31.2%) were male among 170 patients with AAV (88 microscopic polyangiitis, 43 granulomatosis with polyangiitis, and 39 eosinophilic granulomatosis with polyangiitis). ANCA was detected in 129 patients (75.9%). The initial mean CRP and serum albumin were 41.1 (mg/L) and 3.6 (g/dL), and the mean CAR at diagnosis was 14.8. The most common risk factor of mortality was hypertension (42.4%), followed by chronic kidney disease ≥stage 3 (25.9%). Fourteen patients (8.2%) died during the mean follow-up of 56.7 months. In both multivariable Cox hazard model analyses, CAR at diagnosis was identified as an independent predictor of all-cause of mortality comparable to diabetes mellitus (DM). Moreover, patients with CAR ≥10.35 and having DM exhibited a higher frequency of all-cause mortality than those without. CONCLUSION: CAR at diagnosis can be an independent predictor of all-cause mortality, comparable to DM, the conventional risk factor of mortality.
