Protective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer.
10.4174/astr.2018.95.3.161
- Author:
Jeonghyun KANG
1
;
Joon Seong PARK
;
Sung Gwe AHN
;
Jin Hong LIM
;
Seung Hyuk BAIK
;
Dong Sup YOON
;
Kang Young LEE
;
Joon JEONG
Author Information
1. Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. gsjjoon@yuhs.ac
- Publication Type:Original Article
- Keywords:
Oxaliplatin;
Splenomegaly;
Colonic neoplasms;
Folfox protocol
- MeSH:
Colon*;
Colonic Neoplasms*;
Drug Therapy;
Fluorouracil;
Humans;
Leucovorin;
Multivariate Analysis;
Panax*;
Retrospective Studies;
Spleen;
Splenomegaly*
- From:Annals of Surgical Treatment and Research
2018;95(3):161-167
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study investigated how adding Korean red ginseng extract (KRG) to folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy affected the rate of splenomegaly in colon cancer. METHODS: This retrospective study analyzed 42 patients who were randomly assigned to receive a FOLFOX regimen with or without KRG. Spleen volume change was assessed by computed tomography scans measured before surgery (presurgery volume) and 3 weeks after cessation of the 12th cycle of FOLFOX (postchemotherapy volume). RESULTS: All patients showed increased spleen volume. No difference was observed in median presurgery and postchemotherapy volume between the KRG and control groups. However, a ratio defined as postchemotherapy volume divided by presurgery volume was significantly lower in the KRG group than the control group (median, 1.38 [range, 1.0–2.8] in KRG group vs. median, 1.89 [range, 1.1–3.0] in control group, P = 0.028). When splenomegaly was defined as a >61% increase in spleen volume, the rate of splenomegaly was significantly lower in the KRG group than the control group (28.6% vs. 61.9%, P = 0.03). KRG consumption was inversely associated with developing splenomegaly in multivariate analysis. CONCLUSION: Adding KRG during FOLFOX chemotherapy for colon cancer might protect against oxaliplatin-induced splenomegaly. The protective effect of Korean red ginseng should be investigated with further research.
