Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer.
- Author:
Jong Lyul PARK
1
;
Seon Kyu KIM
;
Jeong Hwan KIM
;
Seok Joong YUN
;
Wun Jae KIM
;
Won Tae KIM
;
Pildu JEONG
;
Ho Won KANG
;
Seon Young KIM
Author Information
- Publication Type:Original Article
- Keywords: castration-resistant prostate cancer; DNA variants; whole-genome sequencing
- MeSH: Dataset; Genome; Humans; Prognosis; Prostate*; Prostatic Neoplasms*
- From:Genomics & Informatics 2018;16(3):71-74
- CountryRepublic of Korea
- Language:English
- Abstract: Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CRPC tissues compared with primary PC tissues (range, 1,691 to 21,705). Our whole-genome sequencing data of primary PC and CRPC may be useful for understanding the genomic changes and molecular mechanisms that occur during the progression from PC to CRPC.
