Therapeutic Effects of Leuprorelin (Leuprolide Acetate) in Sexual Offenders with Paraphilia.
10.3346/jkms.2018.33.e231
- Author:
Jong Hyuk CHOI
1
;
Jae Woo LEE
;
Jang Kyu LEE
;
Soyeong JANG
;
Mi YOO
;
Dae bo LEE
;
Jeong Won HONG
;
Il Suk NOH
;
Myung Ho LIM
Author Information
1. Department of Psychiatry, National Forensic Hospital, Gongju, Korea.
- Publication Type:Original Article
- Keywords:
Leuprorelin;
Leuprolide Acetate;
Sexual Offenders;
Paraphilia
- MeSH:
Criminals*;
Diagnostic and Statistical Manual of Mental Disorders;
Fantasy;
Fatigue;
Feminization;
Humans;
Leuprolide*;
Paraphilic Disorders*;
Psychiatry;
Sexual Behavior;
Social Justice;
Therapeutic Uses*
- From:Journal of Korean Medical Science
2018;33(37):e231-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This study examined the clinical effects of leuprolide acetate in sexual offenders with paraphilic disorders evaluated by means of objective psychiatric assessment. METHODS: The subjects of this study were seven sexual offenders who were being treated by means of an injection for sexual impulse control by a court order. They had been diagnosed with paraphilia by a psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and had been put on probation by the Ministry of Justice between January 2016 and December 2016. RESULTS: After twelve months, we observed significant improvement in symptoms, as decrease of abnormal sexual interest and activity, sexual fantasy, Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Impulsivity (GCI-I). There were a mild feminization of the body shape, feelings of fatigue, and mild hot flushes. No other adverse effect was reported. CONCLUSION: These results suggested that the clinical effects of leuprolide acetate in sexual offenders might be an effective treatment and safety strategy.
