Molecular Diagnosis of Thyroid Nodule.
10.3342/kjorl-hns.2018.00493
- Author:
Yong Bae JI
1
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Korea. jyb20000@hanyang.ac.kr
- Publication Type:Review
- Keywords:
Diagnosis;
Genetic testing;
Molecular diagnostic techniques;
Thyroid carcinoma;
Thyroid nodule
- MeSH:
Biomarkers;
Biopsy, Fine-Needle;
Carcinogenesis;
Classification;
Diagnosis*;
Diagnostic Tests, Routine;
Genetic Testing;
Methods;
Molecular Diagnostic Techniques;
Thyroid Gland*;
Thyroid Neoplasms;
Thyroid Nodule*
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2018;61(9):445-452
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Fine needle aspiration cytology is gold standard for diagnosis of thyroid nodule. However, it is not perfect and its results are cytologically indeterminate nodules (Bethesda classification III-V) in 15-30%, which remains diagnostic challenges. So, the method that provide information about cancer risk is necessary to establish management strategy. As results of studies about genetic changes in thyroid cancer, remarkable advances have been achieved in understanding thyroid carcinogenesis, which produced applications of molecular biomarkers and profiling panels for diagnosis of thyroid nodule. These tests help clinicians make decision regarding the need for surgery and the surgical extent. In this review, published researches related to molecular diagnosis of thyroid cancer are reviewed and performance of the diagnostic tests and its interpretation were discussed.
