Impact of the Endothelial Tight Junction Protein Claudin-5 on Clinical Profiles of Patients With COPD.
10.4168/aair.2018.10.5.533
- Author:
Byeong Gon KIM
1
;
Pureun Haneul LEE
;
Sun Hye LEE
;
Ae Rin BAEK
;
Jong Sook PARK
;
Junehyuk LEE
;
Sung Woo PARK
;
Do Jin KIM
;
Choon Sik PARK
;
An Soo JANG
Author Information
1. Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. jas877@schmc.ac.kr
- Publication Type:Original Article
- Keywords:
Tight junctions;
claudin-5;
COPD
- MeSH:
Claudin-5*;
Forced Expiratory Volume;
Humans;
Permeability;
Plasma;
Pulmonary Disease, Chronic Obstructive*;
Sample Size;
Smoke;
Smoking;
Tight Junctions*
- From:Allergy, Asthma & Immunology Research
2018;10(5):533-542
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The tight junction protein claudin-5 (CLDN5) is critical to the control of endothelial cellular polarity and pericellular permeability. The role of CLDN5 in chronic obstructive pulmonary disease (COPD) remains unclear. The aim of this study was to investigate the association between CLDN5 levels and clinical variables in patients with COPD. METHODS: In total, 30 patients with COPD and 30 healthy controls were enrolled in the study. The plasma CLDN5 level was checked in patients with stable or exacerbated COPD and in healthy controls. RESULTS: The mean plasma CLDN5 level of patients with COPD was 0.63 ± 0.05 ng/mL and that of healthy controls was 6.9 ± 0.78 ng/mL (P = 0.001). The mean plasma CLDN5 level was 0.71 ± 0.05 ng/mL in exacerbated COPD patients and 0.63 ± 0.04 ng/mL in patients with stable COPD (P < 0.05). The plasma CLDN5 level among COPD subjects was correlated with the smoking amount (r = −0.530, P = 0.001). The plasma CLDN5 level in stable COPD patients was correlated with forced expiratory volume in one second (FEV1, %pred.) (r = −0.481, P = 0.037). CONCLUSIONS: The plasma CLDN5 level was not correlated with age. CLDN5 may be involved in the pathogenesis of COPD. Further studies having a larger sample size will be needed to clarify CLDN5 in COPD.
