The effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer.
10.5468/ogs.2018.61.5.615
- Author:
Seul LEE
1
,
2
;
Yun Hwa KIM
;
Seung Chul KIM
;
Jong Kil JOO
;
Dong Suh SEO
;
Ki Hyung KIM
;
Kyu Sup LEE
Author Information
1. Department of Obstetrics and Gynecology, School of Medicine
2. Biomedical Research Institute, Pusan National University Hospital, Busan, Korea. jkjoo@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Tamoxifen;
Endometrium;
Breast neoplasms;
Ovary
- MeSH:
Biopsy;
Breast Neoplasms*;
Breast*;
Endometrial Hyperplasia;
Endometrial Neoplasms;
Endometrium*;
Female;
Follow-Up Studies;
Gynecological Examination;
Humans;
Medical Records;
Ovarian Cysts*;
Ovary;
Polyps;
Prevalence;
Retrospective Studies;
Tamoxifen*;
Ultrasonography
- From:Obstetrics & Gynecology Science
2018;61(5):615-620
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To evaluate the effect of tamoxifen on female reproductive organs in women with breast cancer. METHODS: We retrospectively reviewed the medical records of 309 women with breast cancer who were currently receiving tamoxifen and undergoing regular gynecological examination. RESULTS: We evaluated 92 pre- and 217 postmenopausal women. The prevalence of endometrial thickening was 12% in the pre- and 10.6% in the postmenopausal group. An endometrial biopsy was performed in 43 women and confirmed endometrial cancer in 1, endometrial polyps in 14, and endometrial hyperplasia in 4 women. Transvaginal ultrasonography showed 25 cases of newly developed ovarian cysts. Most ovarian cysts had disappeared during follow-up. CONCLUSION: Tamoxifen use in women with breast cancer causes few complications and is considered safe for female reproductive organs in case of regular gynecological examination.
