Anaphylactic shock to vaginal misoprostol: a rare adverse reaction to a frequently used drug.
10.5468/ogs.2018.61.5.636
- Author:
Hyun Joo SHIN
1
;
Sa Ra LEE
;
A mi ROH
;
Young mee LIM
;
Kyung Ah JEONG
;
Hye Sung MOON
;
Hye Won CHUNG
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Korea. sarahmd@ewha.ac.kr
- Publication Type:Case Report
- Keywords:
Anaphylaxis;
Shock;
Hysteroscopy;
Misoprostol
- MeSH:
Anaphylaxis*;
Cervical Ripening;
Dilatation and Curettage;
Female;
Fever;
Humans;
Hypotension;
Hysteroscopy;
Labor Stage, First;
Middle Aged;
Misoprostol*;
Mortality;
Pregnancy;
Pregnant Women;
Shock
- From:Obstetrics & Gynecology Science
2018;61(5):636-640
- CountryRepublic of Korea
- Language:English
-
Abstract:
Misoprostol is widely used in daily practice for induction of labor and cervical dilatation prior to intrauterine procedures, including dilatation and curettage or hysteroscopy. Anaphylactic shock to intravaginal misoprostol can occur not only in pregnant women, as reported in 2 previous cases, but also in a non-pregnant, perimenopausal woman, as in the case described herein. A 49-year-old woman received vaginal misoprostol for cervical ripening prior to hysteroscopic myomectomy and experienced anaphylactic shock. Two 400 μg doses of misoprostol 6 hours apart caused uncontrolled shaking and high fever followed by shock. In conclusion, the possibility of anaphylactic shock should be considered in patients with sudden hypotension following misoprostol administration. Prompt identification and management are crucial to prevent morbidity and mortality following an anaphylactic shock to misoprostol.
