Clinical significance of Th17 cells in kidney transplantation.
- Author:
Byung Ha CHUNG
1
;
Chul Woo YANG
;
Mi La CHO
Author Information
- Publication Type:Review
- Keywords: Allograft rejection; Chronic allograft dysfunction; Kidney transplantation; Mammalian target of rapamycin; Th17 cells
- MeSH: Allografts; Kidney Transplantation*; Kidney*; Plasma; T-Lymphocytes; Th17 Cells*
- From:The Korean Journal of Internal Medicine 2018;33(5):860-866
- CountryRepublic of Korea
- Language:English
- Abstract: Transplantation research has focused on cytotoxic T-cell and plasma cell/B-cell-targeted strategies, but little attention has been paid to the role of T helper 17 (Th17) cells in allograft dysfunction. However, accumulating evidence suggests that Th17 cells contribute to the development of acute and chronic allograft injury after transplantation of various organs, including the kidney. This review summarizes recent reports on the role of Th17 cells in kidney transplantation. Means of improving allograft outcomes by targeting the Th17 pathway are also suggested.
