The incidence of venous thromboembolism is not lowin Korean patients with advanced pancreatic cancer.
- Author:
Seug Yun YOON
1
;
Min Young LEE
;
Jina YOON
;
Han Jo KIM
;
Kyoung Ha KIM
;
Se Hyung KIM
;
Sang Cheol LEE
;
Sang Byung BAE
;
Chan Kyu KIM
;
Nam Su LEE
;
Kyu Taek LEE
;
Sung Kyu PARK
;
Dae Sik HONG
;
Jong Ho WON
Author Information
- Publication Type:Original Article
- Keywords: Korean; Advanced pancreatic cancer; Venous thromboembolism
- MeSH: Asian Continental Ancestry Group; Diagnosis; Drug Therapy; Hospitals, University; Humans; Incidence*; Medical Records; Pancreatic Neoplasms*; Prognosis; Pulmonary Embolism; Retrospective Studies; Thrombosis; Veins; Venous Thromboembolism*; Venous Thrombosis
- From:Blood Research 2018;53(3):227-232
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Pancreatic cancer is among the most common malignancies associated with venous thromboembolism (VTE). Asian patients are known to have a lower incidence of VTE compared to Caucasian patients. However, few studies have investigated the incidence of VTE in Asian patients with pancreatic cancer. METHODS: This retrospective review of medical records was performed on 505 patients with histopathologically proven advanced stage pancreatic cancer, from January 2006 to December 2012, at Soonchunhyang University Hospitals. RESULTS: Ninety-four patients (18.6%) had at least one pulmonary embolism (PE), deep vein thrombosis (DVT), or splanchnic vein thrombosis (SVT); 38 patients had isolated SVT; and 56 patients (11.1%) had at least one classic VTE (PE and/or DVT of lower extremities). Patients with more advanced stages of pancreatic cancer (distant metastatic stage, recurrence) or who had received chemotherapy had a higher incidence of classic VTE. Patients who were simultaneously diagnosed with pancreatic cancer and classic VTE had a poorer prognosis than patients with subsequent VTEs. There was a significant difference in overall survival (OS) between the presence and absence of a concurrent classic VTE diagnosis (median: OS, 2.1 mo vs. 10.7 mo; P < 0.001). Even when VTE included SVT, the result was similar (P < 0.001). CONCLUSION: In Korean patients with advanced pancreatic cancer, the incidence of VTEs is comparable to that of Caucasian patients. We also found that pancreatic cancer patients with concurrent VTEs had a poor prognosis compared to patients who developed VTEs later.
