Effects of Long-Distance Running on Cardiac Markers and Biomarkers in Exercise-Induced Hypertension Runners: An Observational Study.
10.5535/arm.2018.42.4.575
- Author:
Min Ho PARK
1
;
Kyung A SHIN
;
Chul Hyun KIM
;
Yoon Hee LEE
;
Yongbum PARK
;
Jaeki AHN
;
Young Joo KIM
Author Information
1. Department of Rehabilitation Medicine, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Exercise;
Hypertension;
Blood pressure;
Biomarkers;
Running
- MeSH:
Biomarkers*;
Blood Pressure;
C-Reactive Protein;
Cardiac Volume;
Cardiovascular System;
Continental Population Groups;
Creatine;
Creatine Kinase;
Exercise Test;
Humans;
Hypertension*;
L-Lactate Dehydrogenase;
Myocardium;
Observational Study*;
Prospective Studies;
Running*;
Troponin I;
Volunteers
- From:Annals of Rehabilitation Medicine
2018;42(4):575-583
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To investigate changes of cardiac and muscle damage markers in exercise-induced hypertension (EIH) runners before running (pre-race), immediately after completing a 100-km ultramarathon race, and during the recovery period (24, 72, and 120 hours post-race). METHODS: In this observational study, volunteers were divided into EIH group (n=11) whose maximum systolic blood pressure was ≥210 mmHg in graded exercise testing and normal exercise blood pressure response (NEBPR) group (n=11). Their blood samples were collected at pre-race, immediately after race, and at 24, 72, and 120 hours post-race. RESULTS: Creatine kinase (CK) and cardiac troponin I (cTnI) levels were significantly higher in EIH group than those in the NEBPR group immediately after race and at 24 hours post-race (all p < 0.05). However, lactate dehydrogenase (LDH), creatine kinase-myocardial band (CKMB), or CKMB/CK levels did not show any significant differences between the two groups in each period. N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were significantly higher in EIH group than those in NEBPR group immediately after race and at 24 and 72 hours post-race (all p < 0.05). A high sensitivity C-reactive protein (hs-CRP) level was significantly higher in EIH group than that in NEBPR group at 24 hours post-race (p < 0.05). CONCLUSION: The phenomenon of higher inflammatory and cardiac marker levels in EIH group may exaggerate cardiac volume pressure and blood flow restrictions which in turn can result in cardiac muscle damage. Further prospective studies are needed to investigate the chronic effect of such phenomenon on the cardiovascular system in EIH runners.
