Clinical characteristics and mortality-predictive factors analyses of glyphosate intoxication.
- Author:
Chang Hun SON
1
;
Suk Hee LEE
;
Tae Chang JANG
;
Gyun Moo KIM
;
Seung Hyun KO
;
Young Woo SEO
Author Information
1. Department of Emergency Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. emseo@cu.ac.kr
- Publication Type:Original Article
- Keywords:
Clinical characteristics;
Glyphosate;
Intoxication;
Mortality
- MeSH:
Blood Glucose;
Blood Pressure;
Creatinine;
Emergency Service, Hospital;
Glucose;
Humans;
Hydrogen-Ion Concentration;
Hypotension;
Lactic Acid;
Medical Records;
Mortality;
Retrospective Studies;
Serum Albumin;
Survivors;
Toxicology
- From:Journal of the Korean Society of Emergency Medicine
2018;29(4):304-311
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Glyphosate intoxicated patients are increasing as glyphosate use increases. This study was conducted to analyze clinical characteristics of glyphosate intoxication patients to provide early treatment to high risk patients. METHODS: We retrospectively collected data pertaining to glyphosate intoxicated patients who visited emergency department from January 2012 to December 2016 based on medical records. The patients were divided into survivors and deaths, after which their clinical characteristics and laboratory results were compared. RESULTS: Among 84 glyphosate intoxicated patients, 12 died (14.3%). The mortality group showed advanced age (P=0.006), low blood pressure (P=0.001), worse mental status (P=0.000), low arterial blood pH (P=0.000), high serum creatinine (P=0.030), high glucose (P=0.000), high serum lactate (P=0.011), and low serum albumin (P=0.034). Logistic multivariate regression analysis revealed that the mortality group had advanced age (odds ratio [OR], 1.193), high serum glucose (OR, 1.018), and low systolic blood pressure (OR, 0.961) compared to the survivor group. CONCLUSION: On the scene and emergency department, glyphosate intoxicated patients with advanced age, high serum glucose level, and low systolic blood pressure should be provided early supportive treatments and transported to a toxicology facility.
