Retinal Toxicity of Repetitive Intravitreal Injections of Amphotericin B.
- Author:
Byung Joon LEE
1
;
Boo Sup OUM
Author Information
1. Department of Ophthalmology, College of Medicine, Pusan National Univerity, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Amphotericin B;
Intravitreal injections;
Retinal toxicity
- MeSH:
Amphotericin B*;
Cataract;
Intravitreal Injections*;
Microscopy;
Rabbits;
Retinaldehyde*
- From:Journal of the Korean Ophthalmological Society
1991;32(7):550-556
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Authors evaluated the retinal toxic reation of intravitreal injection with a regimens of 10 microgram of amphotericin B on both phakic and aphakic eyes of rabbits. In addition to the eye receiving single injection, the effects of repeating the same dose second and third time at interval of 1 week were examined by light microscopy after last injection. The results were as follows: 1. Even a single intravitreal injection with regimens of 10 microgram amphotericin B, vitreous opacities and posterior subcapsular lens opacities were observed ophthalmoscopically. 2. A single and repeated intravitreal injections with regimens of 10 microgram amphotericin B showed focal areas of retinal toxic reation. 3. Lens extraction did not modify the retinotoxic reation of intravitreally administrated amphotericin B. 4. Repetitive intravitreal injection of amphotericin B did not show increasing retinal toxic reation.
