Diagnosing Diabetic Neuropathy: Something Old, Something New.
- Author:
Ioannis N PETROPOULOS
1
;
Georgios PONIRAKIS
;
Adnan KHAN
;
Hamad ALMUHANNADI
;
Hoda GAD
;
Rayaz A MALIK
Author Information
- Publication Type:Review
- Keywords: Complications; Diabetic neuropathies; Diagnosis
- MeSH: Biomarkers; Diabetic Neuropathies*; Diagnosis; Drug Discovery; Microscopy, Confocal; Peripheral Nervous System Diseases; United States Food and Drug Administration
- From:Diabetes & Metabolism Journal 2018;42(4):255-269
- CountryRepublic of Korea
- Language:English
- Abstract: There are potentially many ways of assessing diabetic peripheral neuropathy (DPN). However, they do not fulfill U.S. Food and Drug Administration (FDA) requirements in relation to their capacity to assess therapeutic benefit in clinical trials of DPN. Over the past several decades symptoms and signs, quantitative sensory and electrodiagnostic testing have been strongly endorsed, but have consistently failed as surrogate end points in clinical trials. Therefore, there is an unmet need for reliable biomarkers to capture the onset and progression and to facilitate drug discovery in DPN. Corneal confocal microscopy (CCM) is a non-invasive ophthalmic imaging modality for in vivo evaluation of sensory C-fibers. An increasing body of evidence from multiple centers worldwide suggests that CCM fulfills the FDA criteria as a surrogate endpoint of DPN.
