The Use of Normal Stem Cells and Cancer Stem Cells for Potential Anti-Cancer Therapeutic Strategy.
10.1007/s13770-018-0128-8
- Author:
Seung Woo HAN
1
;
Yoon Young KIM
;
Woo Ju KANG
;
Hyoung Chin KIM
;
Seung Yup KU
;
Byeong Cheol KANG
;
Jun Won YUN
Author Information
1. Department of Biotechnology, The Catholic University of Korea, 43 Jibongro, Bucheon 14662, Republic of Korea. bckang@snu.ac.kr
- Publication Type:Review
- Keywords:
Cancer;
Stem cell;
Cancer stem cell;
Targeted cancer therapy;
Marker
- MeSH:
Biology;
Diagnosis;
Drug Therapy;
Immunotherapy;
Incidence;
Mortality;
Neoplastic Stem Cells*;
Radiotherapy;
Regeneration;
Stem Cells*
- From:
Tissue Engineering and Regenerative Medicine
2018;15(4):365-380
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Despite recent advance in conventional cancer therapies including surgery, radiotherapy, chemotherapy, and immunotherapy to reduce tumor size, unfortunately cancer mortality and metastatic cancer incidence remain high. Along with a deeper understanding of stem cell biology, cancer stem cell (CSC) is important in targeted cancer therapy. Herein, we review representative patents using not only normal stem cells as therapeutics themselves or delivery vehicles, but also CSCs as targets for anti-cancer strategy. METHODS: Relevant patent literatures published between 2005 and 2017 are discussed to present developmental status and experimental results on using normal stem cells and CSCs for cancer therapy and explore potential future directions in this field. RESULTS: Stem cells have been considered as important element of regenerative therapy by promoting tissue regeneration. Particularly, there is a growing trend to use stem cells as a target drug-delivery system to reduce undesirable side effects in non-target tissues. Noteworthy, studies on CSC-specific markers for distinguishing CSCs from normal stem cells and mature cancer cells have been conducted as a selective anti-cancer therapy with few side effects. Many researchers have also reported the development of various substances with anticancer effects by targeting CSCs from cancer tissues. CONCLUSION: There has been a continuing increase in the number of studies on therapeutic stem cells and CSC-specific markers for selective diagnosis and therapy of cancer. This review focuses on the current status in the use of normal stem cells and CSCs for targeted cancer therapy. Future direction is also proposed.
