Wicking Property of Graft Material Enhanced Bone Regeneration in the Ovariectomized Rat Model.
10.1007/s13770-018-0142-x
- Author:
Seunghyun KIM
1
;
Taeho AHN
;
Myung Ho HAN
;
Chunsik BAE
;
Daniel S OH
Author Information
1. College of Veterinary Medicine, Chonnam National University, 77 Yongbong-ro, Gwangju 61186, Republic of Korea. csbae210@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Bone regeneration;
Hydroxyapatite;
Osteoporosis;
Bone void filler
- MeSH:
Animals;
Bone Regeneration*;
Capillary Action*;
Durapatite;
Heterografts;
Methods;
Models, Animal*;
Osteogenesis;
Osteoporosis;
Rats*;
Stem Cells;
Transplants*
- From:
Tissue Engineering and Regenerative Medicine
2018;15(4):503-510
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Recruitment and homing cells into graft materials from host tissue is crucial for bone regeneration. METHODS: Highly porous, multi-level structural, hydroxyapatite bone void filler (HA-BVF) have been investigated to restore critical size bone defects. The aim was to investigate a feasibility of bone regeneration of synthetic HA-BVF compared to commercial xenograft (Bio-Oss). HA-BVF of 0.7 mm in average diameter was prepared via template coating method. Groups of animals (n = 6) were divided into two with normal (Sham) or induced osteoporotic conditions (Ovx). Subsequently, subdivided into three treated with HA-BVF as an experiment or Bio-Oss as a positive control or no treatment as a negative control (defect). The new bone formation was analyzed by micro-CT and histology. RESULTS: At 4 weeks post-surgery, new bone formation was initiated from all groups. At 8 weeks post-surgery, new bone formation in the HA-BVF groups was greater than Bio-Oss groups. Extraordinarily greater bone regeneration within the Ovx-HA group than Sham-Bio-Oss or Ovx-Bio-Oss group (p<0.05). CONCLUSION: This study suggests that the immediate wicking property of HA-BVF from host tissue activates a natural healing cascade without the addition of exogeneous factors or progenitor cells. HA-BVF may be an effective alternative for repairing bone defects under both normal and osteoporotic bone conditions.
