Three Cases of Generalized Granuloma Annulare Successfully Treated with Methotrexate.
- Author:
Sang Jin CHEON
1
;
Sungmin PARK
;
Hyun Joo LEE
;
Taewook KIM
;
Hyunju JIN
;
Hyangsuk YOU
;
Woo Haing SHIM
;
Gun Wook KIM
;
Hoon Soo KIM
;
Hyun Chang KO
;
Moon Bum KIM
;
Byung Soo KIM
Author Information
1. Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea. dockbs@pusan.ac.kr
- Publication Type:Case Report
- Keywords:
Generalized granuloma annulare;
Recalcitrant;
Methotrexate
- MeSH:
Dapsone;
Granuloma Annulare*;
Granuloma*;
Hydroxychloroquine;
Isotretinoin;
Methotrexate*;
Phototherapy;
Skin Diseases;
Steroids
- From:Korean Journal of Dermatology
2018;56(7):437-442
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Granuloma annulare is a benign granulomatous skin disease, clinically characterized by dermal papules tending to form annular shapes. Granuloma annulare is classified into localized, generalized, subcutaneous, and perforating types. Localized granuloma annulare is likely to resolve spontaneously, while generalized granuloma annulare usually takes a chronic course. Topical steroids, phototherapy, isotretinoin, dapsone, hydroxychloroquine, and other various treatments have been proposed, but some cases have been resistant to all of those treatment modalities. We experienced 3 cases of generalized granuloma annulare demonstrating a recalcitrant course that were successfully treated with methotrexate and propose that methotrexate may be an effective option for recalcitrant generalized granuloma annulare treatment.
